This research was designed to examine the relationship between Human Resource Management and Management Information System in a Select Deposit Money Banks in Akwa Ibom State. A survey research design was adopted for the study and a sample size of 181 respondents was drawn from the population of 330. For the objective of the study to be achieved, four hypotheses were formulated. The major instrument for data collection was a structured questionnaire administered to the respondents using Random Sampling Techniques. Data collected were analyzed using simple percentage and Pearson Product Moment Correlation. Results show that there is a significant correlation between system software, Supervisor support, employee network design, business and process knowledge and Management Information System. Based on the finding of the analysis, it is concluded that Software design, supervisor support, employee network design, business and process knowledge are significant positive determinants of Human resource management. Companies that consider the application of management information system dimensions are likely to record a better HRM Key Performance Indicators (KPI). Although all four (4) management information system dimensions were strongly correlated, the coefficient for business and process knowledge was seen as the dimension that had the highest significant influence at 0.874 on the human resource. Consequently, it is recommended that Deposit Money Banks in Akwa Ibom State should help in the development of human resources management information system to measuring goals through training programs.
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