Evaluating In Vivo Antiplasmodial Potency of Aqueous Extract of Phyllanthus Niruri in Swiss Albino Mice

Abstract

In vivo antiplasmodial potency of aqueous leaf extract of phallanthus niruri used in malaria naturopathy, a global public health scourge was evaluated in unsexed 100 4-week old, 5 groups of 20 swiss albino mice each weighing 18-22g passaged with rodent plasmodium berghei NK-65 except Sham. Control/Sham received distilled water. Other 3 groups received 200, 400; 800mg/kg of extract respectively and focally/histologically sampled for 7 consecutive days (d). After 7d, Control exhibited high density load of parasitemia, marked lethargy, white eyelids and extreme hemodilution compared to treated groups. % residual parasitic density with time (d) were 35 + 4% (200mg/kg), 13 + 1% (400mg/kg), 10 + 1% (800mg/kg) compared to 65 + 7% (Control) with Ct½ 1.4 < 2.3 < 4.8 < 7d : 800 < 400 < 200mmkg < Control (p < 0.05). No adverse renal or hepatic effects. These results strongly demonstrate a potent safe in vivo antiplasmodial activity of P. niruri.

Keywords: antiplasmodial activity, aqueous leaf extract, phyllanthus niruri, swiss albino mice.

Article Review Status: Published

Pages: 35-46 (Download PDF)

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