Free Radical Scavenging Activities of Extracts and Bioactive Constituents from the Roots of Plumbago Zeylanica (Linn.)

Abstract

Bioactive constituents from the methanolic extract (ME) and ethylacetate extract (EA) of Plumbago zeylanica were characterized by gas chromatography-mass spectrometry. The free radical scavenging activities of ME and EA was determined using 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Major bioactive compounds found in the ME includes oxalic acid allyltridecyl ester, decane, 2-piperidinone-N-[4-bromo-n-butyl] and tetradecane, compounds obtained from EA were 1-(ethenyloxyl) octadecane and cis-13-octadecenoic acid. Cis-13-octadecenoic acid, though known, was isolated for the first time from the root of P. zeylanica. The highest percentage antioxidant activities of ME and EA were 98.5% and 45.5% respectively at 350 µg/ml concentration of extracts. Results obtained from this study justify the use of P. zeylanica in traditional medicine for treatment of different ailments and it could be a potential source for novel drug compounds.

Keywords: DPPH, Plumbago zeylanica, bioactive compounds, gas chromatography-mass spectrometry


Article Review Status: Published

Pages: 21-33 (Download PDF)

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