Ten isolates, from 25 skin scraping of cutaneous infected site were diagnosed as Candida albicans. Infection with C.albicans was the highest among females than males with a rate of 80% and 20% respectively, and among patients with age 21-30 years(40%).In vitro antifungal susceptibility of ketoconazole, fluconazole,Nystatin, Amphotericin–B and Clotrimazole against clinical isolates of C. albicans indicate that the yeast isolates were susceptible (100%)to four antifungal ,while 3 out of isolates were resistance to fluconazole with inhalation zone 20.4mm.The in vitro study using the seed extracts of Carica papaya at concentrations 10%,25% and 50% inhibited the growth of C. albicans with rate 10mm, 9mm,8mm, respectively compatible with control(0%) 15mm. In vivo antifungal activity studies on candidiasis in mice treated with the seed extract (2.5g/kg body weight ),liver showed infiltration in lymphocyte and hydropic degeneration, while spleen and kidney showed in filtration of lymphocyte ,compatible with negative control(not treatment) and positive control treated with ketoconazole .
Keywords: Antifungal activity, Candida albicans, Carica Papaya, anticandida activity
