DISINTEGRATION OF THE ISLET CELLS (OF LANGERHANS) FOLLOWING THE ADMINISTRATION OF ETHANOLIC EXTRACTS OF GINGER IN ADULT WISTAR RATS

Abstract

This study elucidates the effect of ethanolic extract of ginger on the histology of the pancreas. Forty adult wistar rats weighing 190-200g were divided into five groups designated A, B, C, D, and E; each group containing eight experimental animals. The animals in groups A and B served as the control receiving distil water and olive oil respectively. The animals in group C, D, and E received 100mg/kg, 250mg/kg and 500mg/kg body weight of ethanolic extract of ginger respectively for fourteen days. Twenty four hours after the last administration, the animals were sacrificed; the pancreas was removed and processed in routine histological technique. Under the light microscope, the result showed normal exocrine part and disintegration of the islet cells (of Langerhans) with pyknotic nuclei. This study showed that the effect on the islet of Langerhan increases as the consumption increases

Keywords: Wistar rats, ginger, pancreas


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