Implication of Renal Based Mechanism for Anti-Ultraviolet Ray Response to Organic Turmeric Supplement in Rabbits

Abstract

Recent investigations failed to establish hepatic system as primary mechanistic locus for anti-UV effects of organic turmeric (T) in rabbits. Current effort, sought possible implication of renal mechanisms. Study was for 85days (d) in three phased periods: 40d pre-irradiation, 5d irradiation and 40d post-irradiation in 48 acclimatized rabbits randomly assigned to 4 groups of 12 each, fed unsupplemented diet and forage (Tridax procumbens) – basal diet (BD) and BD supplemented with 2% pulverized crude T. Feed and water were available ad libitum. Blood was collected on 86d from 0900h for measurement of renal parameters. Plasma (p) concentrations ( [ ]p ) of electrolytes were determined by flame photometry; urea, creatinine (CR) and HCO3- by standard titrimetric/colorimetric methods. Data were analyzed by ANOVA. [Na+]p and [HCO3-]p in Control and T groups were statistically similar (p>0.05). UV moderated [Na+]p, [HCO3-]p and [Urea]p at 70% of control value (%C) and elevated [CR]p – %C 140, 100, 100: R, P, T groups respectively (p<0.05). T improved [K+]p and revised suppressed [Urea]p at %C 70, 80, 90: R, P, T groups respectively (p<0.05). These results strongly implicate renal system as a primary mechanistic locus.

Keywords: Prophylaxis, Rabbits, Renal-mechanism, Turmeric, Ultraviolet radiation


Article Review Status: Published

Pages: 48-56 (Download PDF)

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